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How do EV cargo signatures relate to metastatic progression?
EV cargo signatures — particularly miRNA and surface-protein content — track closely with metastatic progression1. Tetraspanin-mediated sorting enriches pro-metastatic cargo, while ESCRT-dependent pathways contribute distinct markers2.
Citations
- 1Nature Communications2024 · p. 4
- 2Cell2025 · p. 118
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Extracellular vesicles as biomarkers in metastatic melanoma
Nature Communications · 2024
Mechanism of miRNA cargo sorting in extracellular vesicles
Cell · 2025
EV-based diagnostics for early detection of cancer metastasis
Science Translational Medicine · 2023
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Paper Summary
This study identifies EV-derived proteins associated with melanoma metastasis and validates biomarkers in patient samples.
Hypothesis
EV cargo reflects metastatic phenotype.
Methods
EV isolation, proteomics, cohort analysis.
Results
3 biomarkers strongly associated with progression.
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68 references linked and traceable.
Citations
- 1
Nature Communications
2024 · p. 4
- 2
Cell
2025 · p. 118
- 3
Sci. Transl. Med.
2023 · p. 7
- 4
J. Extracell. Vesicles
2024 · p. 22
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Experiment EV-2024-041
Edited 2h agoObjective
Isolate and characterize EVs from metastatic melanoma cell lines.
Protocol
EV Isolation Protocol v2.1
Observations
High yield in 72h collection. EV size distribution within expected range.
Metadata
Author
Dr. Jane Smith
Date
May 9, 2026
Project
EV Biomarkers
Tags
EV · Melanoma · qEV
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- Penicillin-Streptomycin15140-1226Freezer −20°C
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EV Biomarkers
Shared by Dr. Jane Smith
128 files · 128 ready · Updated May 2026
Metastasis Review
Shared by Sarah Johnson
42 files · 30 ready · Updated May 2026
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